- The best American science and nature writing 2021, Ed Yong, editor
- Midnight's borders, a people's history of modern India, Suchitra Vijayan
- Yayoi Kusama covered everything in dots and wasn't sorry, by Fausto Gilberti
- Go for the moon, a rocket, a boy, and the first moon landing, Chris Gall
- Cosmic queries, StarTalk's guide to who we are, how we got here, and where we're going, Neil deGrasse Tyson with James Trefil ; read by Neil deGrasse Tyson and Lauren Fortgang
- Ivy the very determined dog, a true story, by Chris and Maureen Harrington ; illustrated by Charlotte Bruijn
- Our Lunar New Year, celebrating Lunar New Year in Asian communities, Yobe Qiu ; [illustrations credits to: Maria Christina Lopez, Jennifer Prevatt, Pui Yu Chan]
- Hold on to your music, the inspiring true story of the children of Willesden Lane, by Mona Golabek and Lee Cohen ; adapted by Emil Sher ; illustrated by Sonia Possentini
- Ocean!, waves for all, by Ocean (with Stacy McAnulty) ; illustrated by Ocean (and David Litchfield)
- Mars!, Earthlings welcome, by Mars (with Stacy McAnulty) ; illustrated by Mars (and Stevie Lewis)
- The elements, written by Adrian Dingle
- Cat, written by Juliet Clutton-Brock
- Ducks overboard!, a true story of plastic in our oceans, Markus Motum
- If you had your birthday party on the Moon, by Joyce Lapin ; illustrated by Simona Ceccarelli
- Only one, by Deborah Hopkinson ; illustrated by Chuck Groenink
- The ocean disaster, Matthew McElligott
- Señorita Mariposa, Ben Gundersheimer also known as Mister G ; illustrated by Marcos Almada Rivero
- The last winter, the scientists, adventurers, journeymen, and mavericks trying to save the world, Porter Fox
- Opal Lee and what it means to be free, the true story of the grandmother of Juneteenth, by Alice Faye Duncan ; illustrations by Keturah A Bobo
- The secret life of the sea otter, Laurence Pringle ; illustrated by Kate Garchinsky
- Microwaves, by Tracy Vonder Brink
- The XX brain, the groundbreaking science empowering women to maximize cognitive health and prevent Alzheimer's disease, Lisa Mosconi, PhD ; foreword by Maria Shriver
- Tomie dePaola's the quicksand book, Tomie dePaola
- Mars!, Earthlings welcome, by Mars ; (with Stacy McAnulty) ; illustrated by Mars (and Stevie Lewis)
- Four hundred souls, a community history of African America 1619-2019, edited by Ibram X. Kendi
- The meaning of pride, written by Rosiee Thor ; illustrated by Sam Kirk
- Sandy feet! whose feet?, footprints at the shore, written by Susan Wood and illustrated by Steliyana Doneva
- Ocean!, waves for all, by Ocean (with Stacy McAnulty) ; illustrated by Ocean (and David Litchfield)
- The moon book, by Gail Gibbons
- Jane against the world, Roe v. Wade and the fight for reproductive rights, Karen Blumenthal
- Hiders seekers finders keepers, how animals adapt in winter, written by Jessica Kulekjian ; illustrated by Salini Perera
- Wild dogs and canines!, by Martin Kratt and Chris Kratt
- Until further notice, a year in pandemic time, Amy Kaler
- Alphamaniacs, builders of 26 wonders of the word, [by] Paul Fleischman ; art by Melissa Sweet
- The key from Spain, Flory Jagoda and her music, by Debbie Levy ; illustrated by Sonja Wimmer
- Moon!, Earth's best friend, by Stacy McAnulty ; illustrated by Stevie Lewis
- How to bake a universe, Alec Carvlin ; illustrated by Brian Biggs
- Archaeologists on a dig, Sue Fliess ; illustrated by Mia Powell
- I am the shark, written by Joan Holub ; illustrated by Laurie Keller
- Día de los muertos, Roseanne Greenfield Thong ; illustrated by Carles Ballesteros
- The view from the cheap seats, selected nonfiction, Neil Gaiman
- A history of underwear with Professor Chicken, written by Hannah Holt ; illustrated by Korwin Briggs
- Cleopatra tells all!, Chris Naunton ; illustrated by Guilherme Karsten
- 300 arguments, Sarah Manguso
- The creative lives of animals, Carol Gigliotti
- Grandma's gardens, written by Hillary Clinton and Chelsea Clinton ; illustrated by Carme Lemniscates
- The whale who swam through time, a 200-hundred-year journey in the Arctic, written by Alex Boersma and Nick Pyenson ; illustrated by Alex Boersma
- The tyranny of merit, what's become of the common good?, Michael J. Sandel
- Come to this court & cry, how the Holocaust ends, Linda Kinstler
- Moon!, Earth's best friend, by Moon (with Stacy McAnulty) ; illustrated by Moon (and Stevie Lewis)